Technological advances in nano manufacturing have led to the development of next-generation silicone probes, which permit in-vivo recordings from hundreds of neurons simultaneously with single-cell spatial and sub-millisecond temporal resolution, resulting in complex large-scale data sets. However, extracting relevant information from these data sets to understand brain function remains a major challenge for the field of systems neuroscience. This seminar provides insight into the process of data acquisition, processing and analysis of large-scale data sets and addresses how to systematize and make sense of the vast amount of accessible information within these data sets